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Mitochondrial-derived peptide
A 16-residue peptide encoded within mitochondrial 12S rRNA, studied as an AMPK-linked regulator of metabolic homeostasis and mitochondrial-to-nuclear signalling.
MOTS-c is one of a small number of known mitochondrial-derived peptides. It has been shown to activate AMPK via the folate–methionine cycle and to translocate to the nucleus under metabolic stress.
Human data is limited to observational measurement of endogenous circulating levels; no human administration trials have been verified. Supplied lyophilised. Not an approved medicine.
| CAS number | 1627580-64-6 |
|---|---|
| Molecular formula | C101H152N28O22S2 |
| Molecular weight | 2174.6 g/mol |
| Purity | ≥98% (HPLC) |
| Sequence | Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (MRWQEMGYIFYPRKLR) |
| Appearance | Lyophilised white powder |
| Storage | Store at -20°C, protect from light |
Every lot we hold of this compound, across all warehouses. The certificate is tied to that lot number — not a generic sample document.
| Lot | Warehouse | Purity | Tested | Laboratory | Documents |
|---|---|---|---|---|---|
| MS40-072026 | All warehouses | 99.24% | 4 Aug 2026 | Freedom Diagnostics Testing | COA |
Preclinical evidence only
The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance
The originating paper: identified MOTS-c and showed AMPK-mediated improvement in insulin sensitivity in mice.
The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress
Established nuclear translocation and regulation of stress-response gene programmes.
MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis
Reported effects on physical capacity in mice alongside measurements in human samples.
Keynote address at Rejuvenation Biotechnology 2016 by Pinchas Cohen, Dean of the USC Leonard Davis School of Gerontology, on mitochondrial-derived peptides. Covers the class broadly rather than MOTS-c alone.
The videos collected here are published by independent third parties. They are provided as educational context only. We did not produce them, we do not endorse them, and nothing in them constitutes guidance, instruction or encouragement to administer any compound to humans or animals.
