Epithalon
Pineal tetrapeptide AEDG
A synthetic tetrapeptide (Ala-Glu-Asp-Gly) studied for reported effects on telomerase expression and telomere length in cultured cells.
Epithalon is the synthetic AEDG tetrapeptide. It should not be confused with "epithalamin", a pineal gland extract used in much of the older Russian literature — the two are routinely conflated, and the extract studies are not epithalon studies.
Evidence is in vitro and rodent only, and originates predominantly from a single research group. Supplied lyophilised. Not an approved medicine.
Specification
| CAS number | 307297-39-8 |
|---|---|
| Molecular formula | C14H22N4O9 |
| Molecular weight | 390.35 g/mol |
| Purity | ≥99% (HPLC) |
| Sequence | Ala-Glu-Asp-Gly (AEDG) |
| Appearance | Lyophilised white powder |
| Storage | Store at -20°C, protect from light |
Batch records & certificates
Every lot we hold of this compound, across all warehouses. The certificate is tied to that lot number — not a generic sample document.
| Lot | Warehouse | Purity | Tested | Laboratory | Documents |
|---|---|---|---|---|---|
| EP25-0162 | India | 99.3% | 14 Jul 2026 | Colmaric Analyticals | COA pending |
| EP25-0155 | United Kingdom | 99.5% | 20 Jun 2026 | Colmaric Analyticals | COA pending |
Published research
Full research profilePreclinical evidence only
Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells
Reported telomerase induction and telomere elongation in cultured human fetal fibroblasts.
Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice
Reported effects on ageing biomarkers and lifespan in mice; one of the few studies using the synthetic tetrapeptide rather than pineal extract.
Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity
Independent replication attempt reporting telomere lengthening across human cell lines via two distinct mechanisms.