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CJC-1295 (DAC)

Long-acting GHRH analogue with drug affinity complex

CJC-1295 (DAC) — 5 mg vial

A tetra-substituted GHRH(1-29) analogue bearing an albumin-binding linker, extending half-life from minutes to an estimated 5.8–8.1 days.

CJC-1295 with DAC carries a maleimidopropionyl group at Lys30 that forms a covalent bond with circulating albumin. This is the molecule described by CAS 446262-90-4.

Note that material marketed as "CJC-1295 no-DAC" or "mod GRF 1-29" is a different compound without the linker and does not share this extended half-life. We list them separately rather than conflating them.

Prohibited in sport under WADA rules. Not an approved medicine.

Specification

CAS number446262-90-4
Molecular formulaC165H269N47O46
Molecular weight3647.2 g/mol
Purity≥98% (HPLC)
AppearanceLyophilised white powder
StorageStore at -20°C, protect from light

Batch records & certificates

Every lot we hold of this compound, across all warehouses. The certificate is tied to that lot number — not a generic sample document.

LotWarehousePurityTestedLaboratoryDocuments
CJ25-0064United States98.3%19 Mar 2026Colmaric AnalyticalsCOA pending

Published research

Full research profile

In human clinical trials

Human clinical

Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults

Teichman SL, et al. · Journal of Clinical Endocrinology & Metabolism · 2006

Randomised placebo-controlled trials in healthy adults showing sustained elevation of GH and IGF-1 after single doses.

PMID 16352683DOI 10.1210/jc.2005-1536
Human clinical

Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog

Ionescu M, Frohman LA · Journal of Clinical Endocrinology & Metabolism · 2006

Demonstrated that GH pulsatility is preserved under continuous GHRH-receptor stimulation, with increased pulse amplitude.

PMID 17018654DOI 10.1210/jc.2006-1702
Animal model

Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse

Alba M, et al. · American Journal of Physiology — Endocrinology and Metabolism · 2006

Restored normal growth in GHRH knockout mice, supporting receptor-mediated activity in vivo.

PMID 16822960DOI 10.1152/ajpendo.00201.2006
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